Unless you use the manual submit feature of the auto submitter programs you run a very high risk of being blacklisted so I don't recommend them.
Submitting by hand is a huge waste of time if you don't have partner status. You won't need partner status at the smaller TGPs because they are still hungry for decent gallery submitters and need to accept any gallery they can get that followed their rules. However, you won't get much traffic from the small TGPs.
Bottom line, you need to work at getting partner status with 30 to 50 medium to large size TGPs and can expect to get 50,000 hits or more a day if you get your gallery accepted at 30 decent size TGPs.
The best way to go about getting partner status is to submit galleries on a daily basis, if possible, to several medium sized TGPs. You probably will accepted to a few each day but your goal at this point is to get the TGP owner used to seeing submissions coming in. After a couple weeks, send an email to every TGP owner with links to at least 5 to 10 galleries you've built so they can see that you've followed their rules, are using good and not overused content and letting them know how many galleries you can submit a week. That's the reason you submitted to them on a regular basis for a couple weeks. To show them that you will actually be submitting good galleries on a frequent basis. They don't want you if you plan on submitting once a week.
If you follow the steps above you will surely get partner status with several of the TGPs you request it from. Now you start name dropping and start the process all over again with the larger TGPs. This time, after you've submitted for a couple weeks and send your email requesting partner status and listing several galleries for them to look at, you also want to list the other TGPs you already have partner status with. TGP owners all know each other, trade traffic with each other and share blacklists, etc. with each other. If you show the large TGP owner that you can produce good quality galleries that follow the rules and they can verify that you are indeed partners with some other TGPs and find out that you are trustworthy, you'll start getting partner status with them too.
We have been doing this for several years and have partner status with every major TGP -- gay and straight -- and are now in the position of having TGP owners contacting us offering us partner status.
Another major benefit to having partner status is that submissions eventually get to be as simple as emailing the links to your list each morning. No submission forms and virtually a matter of only a few minutes each day to submit to a 100 or more TGPs.