Although I am not a hypochondriac, I am however somewhat of a clean freak, especially when it comes to the office and the equipment. The others here do NOT clean, AT ALL, so I am the one that vacuums etc.

I use strong cleaning liquids at the office, such as bleach and ammonia, and white vinegar at home.

After turning over my keyboard and giving it a thorough shake, I use the brush (for the vacuum) on my keyboard.
Next, I completely soak my keyboard and mouse with bleach (in a spray bottle) and let it work, while I do my monitor (with glass cleaner).
I also wash my desktop, at the very least once a week, because I do not like dirty knees ... uh, elbows.

I wash-up after each meal, to help keep the tools clean.