We launched MuscleBearCub.com a few weeks ago with an open source CMS called Joomla.

I'm pretty bright, but I had to job out the set up and the design because it was just too complicated for me. Keep that in mind if you are a one man operation.
For example, I needed my programmer create an instruction manual for me to add new videos. With screen shots, the manual is 11 pages!

On the plus side, there is a lot of buzz about Joomla right now. There are a lot of cheap or free plugins and frequent updates, so it's well supported.

Techies will love the freedom and multitude of choices, creative types will be frustrated. Which are you?